Jobs will also go in Germany and in other parts of Europe.
The carmaker will offer voluntary buyouts for staff and cut jobs for "agency workers and purchased service", it said.
Ford has warned its European operations could suffer losses of $1bn (£630m) this year.
The carmaker has said it does not yet know the final number of axed workers in Europe.
Ford employs 15,000 workers in the UK and has plants at Halewood, Southampton and Dagenham, among others.
In a dispute over pay and pensions, 67% of Ford's UK workers represented by the Unite union - about 1,200 white-collar employees - voted in favour of industrial action after a ballot in May.
"Ford of Europe expects the programmes to result in the reduction of several hundred salaried positions, but exact figures won't be known for a few months," Ford said.
"Any Ford salaried staff separations across all three programmes will be purely voluntary."
Earlier this month, the carmaker unveiled a string of new models, including revamped versions of its best-selling Fiesta, Mondeo and Kuga brands, to revive sales in Europe.
Ford's European chief executive Stephen Odell, speaking at the launch in Amsterdam, said at the time that Europe offered tremendous growth potential in the long term.
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